Age Related Penetrance of HCM
Clinical Diagnosis
Ages:
20
19
18
17
15
12
8
15
11
3
8
7
4
3
2
I
II
III
Gene-based Diagnosis
This slide is an example of  age-related penetrance. Solid symbol show the only 1 member of the younger generation  being affected according to clinical criteria.
Many are genetically positive but don”t yet show any phenotype. In some cases the first disease manifestation might be sudden death.